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KMID : 0614020060210010001
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Journal of Pharmaceutical Sciences (C.N.U.)
2006 Volume.21 No. 1 p.1 ~ p.10
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Regulation of the Multistep Immunity Rejection for Xenotransplantation
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Lee Kwang-Su
Kim Young-Kwan
Park Hee-Jin
Lee Jae-Oh
Myung Pyung-Keun
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Abstract
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The transplantation of organ, tissues or cells between individuals of different species has been of increasing interest in recent years because the use of animals as organ and tissue donors as a source of transplants would overcome the severe and worsening shortage of human organs available for transplantation. However, There are some major hurdles to the clinical application of xenotransplantation; the immunologic response of the recipient against donor, the physiology of the graft, and the possibility that a xenotransplant might transmit an infection from the source to the recipient. This review describes the unique aspects of the immunological barrier to transplanting organs from non-primates such as pigs into humans, focusing especially on the mechanisms which contribute to immunorecognition, physiology of the rejection and infectious hurdles to xenotransplantation. This communication might be applied to overcoming these hurdles and the possibility that genetic strategies might be used to expand the potential applications of xenotransplantation for the treatment of human disease.
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KEYWORD
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xenotransplantation, HAR, AVR, immunosuppression, xenograft rejection
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